Retrospective Analysis of 2295 Cases with Invasive Prenatal Diagnosis
نویسندگان
چکیده
Objective: Retrospective evaluation of the results of the chorion villus sampling, amniocentesis, and cordocentesis of 2295 cases performed for prenatal diagnosis. Methods: Between 2001 and 2007 (first 6 months) 54 cases of genetic chorion villus sampling, 2086 cases of genetic amniocentesis and 155 cases of cordocentesis were evaluated according to indications, success of karyotyping and the results of the karyotyping. Results: The majority of indication was high risk in triple screening test (n= 835, %36), abnormal ultrasonographic examination (n=493, %21), and advanced maternal age (n=490, %21) in all pregnant, respectively. High risk in triple screening test was the major indication in the cases that amniocentesis performed, abnormal ultrasonographic examination in the cases that cordocentesis and chorion villus sampling were performed. Tissues cultures were not successful in 64 of 2086 cases evaluated by AS, 10 of 155 cases evaluated by KS, 5 of 54 cases evaluated by CVS. Cultures were successful 2226 of 2305 cases (%96.4). Chromosome aberration were detected in 98 of 2216 cases (%4.4). 52 (%2.3) of this chromosomal aberration were number abnormalities, 46 of were structural abnormalities. The most frequent chromosomal abnormality was trisomy 21 in the number abnormalities and pericentric inversion of chromosome 9 in structural abnormalities. Karyotype aberration rate was higher in abnormal ultrasonographic examination (%8.8), advanced maternal agehigh risk in triple screening test (%5.1) and advanced maternal age (%3.1). Chromosomal abnormality rate was %2.6 in the most common prenatal diagnosis indication (high risk in triple screening test). Conclusion: The majority of indication was high risk in triple screening test (%36), abnormal ultrasonographic examination (%21), and advanced maternal age (%21) in all pregnant, respectively. Tissues cultures were successful in %96.4 of cases. Chromosome aberration were detected in %4.4 of cases.
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